Thromboangiitis obliterans

I9_THROMBANG

thromboangiitis obliterans: Buerger disease, also known as thromboangiitis obliterans (TAO), is a rare inflammatory non-necrotizing vascular disease affecting the small- and medium-sized arteries and veins of the upper and lower extremities characterized by endarteritis and vaso-occlusion due to occlusive thrombus development. The development and progression of the disease is consistently associated with exposure to tobacco.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I73.1

Hospital discharge: ICD-9 4431A

Hospital discharge: ICD-8 44310

Cause of death: ICD-10 I73.1

Cause of death: ICD-9 4431A

Cause of death: ICD-8 44310

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

I9_THROMBANG

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 I73

Name in latin Tromboangi(i)tis obliterans (Bürger)

Similar endpoints

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List of similar endpoints to Thromboangiitis obliterans based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	85	32	53
Unadjusted prevalence (%)	0.03	0.02	0.04
Mean age at first event (years)	49.77	46.96	51.47

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_THROMBANG – Thromboangiitis obliterans
GWS hits:

Survival analyses between endpoints

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Plot

before Thromboangiitis obliterans
after Thromboangiitis obliterans

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Table

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Drugs most likely to be purchased after Thromboangiitis obliterans

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