myocarditis: Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus , Wegener's granulomatosis , giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and, rarely, a heart transplant may be needed if the heart muscle becomes weak. [ ]

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 I40, I41*
Hospital discharge: ICD-9 422
Hospital discharge: ICD-8 0742|422
Cause of death: ICD-10 I40, I41*
Cause of death: ICD-9 422
Cause of death: ICD-8 0742|422


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1190 470 720
Unadjusted prevalence (%) 0.39 0.27 0.53
Mean age at first event (years) 43.50 46.56 41.50


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.41 [0.77, 7.55] 1.3e-1 125
15 years 0.01 0.82 [0.23, 2.87] 7.6e-1 39
5 years 0.00 3.04 [1.21, 7.64] 1.8e-2 36
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: I9_MYOCARD – Myocarditis
GWS hits: 1

Survival analyses between endpoints


before Myocarditis
after Myocarditis

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