Hypertrophic cardiomyopathy

I9_HYPERTROCARDMYOP

hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I42.1, I42.2

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 I42.1, I42.2

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

839

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

839

Check minimum number of events None

839

Include endpoints None

839

I9_HYPERTROCARDMYOP

Extra metadata

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Hypertrophic cardiomyopathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Heart failure and hypertrophic cardiomyopathy

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

808

324

484

Unadjusted prevalence (%)

0.26

0.19

0.36

Mean age at first event (years)

57.59

55.59

58.93

?

Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	2.72 [1.41, 5.27]	3.0e-3	149
15 years	0.01	1.37 [0.76, 2.46]	2.9e-1	53
5 years	0.01	4.48 [2.82, 7.11]	1.9e-10	46
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_HYPERTROCARDMYOP – Hypertrophic cardiomyopathy
GWS hits: 18

Survival analyses between endpoints

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Plot

before Hypertrophic cardiomyopathy
after Hypertrophic cardiomyopathy

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Hypertrophic cardiomyopathy

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