Hypertrophic cardiomyopathy

I9_HYPERTROCARDMYOP

hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I42.1, I42.2

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 I42.1, I42.2

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

839

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

839

Check minimum number of events None

839

Include endpoints None

839

I9_HYPERTROCARDMYOP

Extra metadata

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Hypertrophic cardiomyopathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Heart failure and hypertrophic cardiomyopathy

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	808	324	484
Unadjusted prevalence (%)	0.26	0.19	0.36
Mean age at first event (years)	57.59	55.59	58.93

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	2.72 [1.41, 5.27]	3.0e-3	149
15 years	0.01	1.37 [0.76, 2.46]	2.9e-1	53
5 years	0.01	4.48 [2.82, 7.11]	1.9e-10	46
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_HYPERTROCARDMYOP – Hypertrophic cardiomyopathy
GWS hits: 18

Survival analyses between endpoints

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Plot

before Hypertrophic cardiomyopathy
after Hypertrophic cardiomyopathy

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Hypertrophic cardiomyopathy

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