Cardiomyopathy, Hypertrophic obstructive


hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 I42.1
Hospital discharge: ICD-9 4251A
Hospital discharge: ICD-8 42500
Cause of death: ICD-10 I42.1
Cause of death: ICD-9 4251A
Cause of death: ICD-8 42500


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF5
Parent code in ICD-10 I42
Name in latin Cardiomyopathia hypertrophica obstructiva

Summary Statistics

Key figures

All Female Male
Number of individuals 433 174 259
Unadjusted prevalence (%) 0.14 0.10 0.19
Mean age at first event (years) 55.48 54.56 56.10


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 3.02 [1.06, 8.60] 3.9e-2 81
15 years 0.01 1.76 [0.78, 3.98] 1.7e-1 33
5 years 0.00 4.11 [2.15, 7.85] 1.9e-5 22
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: I9_CARDMYOHYP – Cardiomyopathy, Hypertrophic obstructive
GWS hits: 16

Survival analyses between endpoints


before Cardiomyopathy, Hypertrophic obstructive
after Cardiomyopathy, Hypertrophic obstructive

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Drugs most likely to be purchased after Cardiomyopathy, Hypertrophic obstructive