Cardiomyopathy, Hypertrophic obstructive

I9_CARDMYOHYP

hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I42.1

Hospital discharge: ICD-9 4251A

Hospital discharge: ICD-8 42500

Cause of death: ICD-10 I42.1

Cause of death: ICD-9 4251A

Cause of death: ICD-8 42500

447

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

447

Check minimum number of events None

447

Include endpoints None

447

I9_CARDMYOHYP

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF5

Parent code in ICD-10 I42

Name in latin Cardiomyopathia hypertrophica obstructiva

Similar endpoints

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List of similar endpoints to Cardiomyopathy, Hypertrophic obstructive based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	433	174	259
Unadjusted prevalence (%)	0.14	0.10	0.19
Mean age at first event (years)	55.48	54.56	56.10

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.02 [1.06, 8.60]	3.9e-2	81
15 years	0.01	1.76 [0.78, 3.98]	1.7e-1	33
5 years	0.00	4.11 [2.15, 7.85]	1.9e-5	22
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_CARDMYOHYP – Cardiomyopathy, Hypertrophic obstructive
GWS hits: 16

Survival analyses between endpoints

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Plot

before Cardiomyopathy, Hypertrophic obstructive
after Cardiomyopathy, Hypertrophic obstructive

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Table

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Drugs most likely to be purchased after Cardiomyopathy, Hypertrophic obstructive

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