Degeneration of macula and posterior pole

DOID MESH PheWeb

H7_MACULADEGEN

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H35.30, H35.31, H35.36#, H35.37#, H35.38#, H35.39#

Hospital discharge: ICD-9 3625

Hospital discharge: ICD-8 37710

Cause of death: ICD-10 H35.30, H35.31, H35.36#, H35.37#, H35.38#, H35.39#

Cause of death: ICD-9 3625

Cause of death: ICD-8 37710

10937

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

10937

Check minimum number of events None

10937

Include endpoints

DRY_AMD

WET_AMD

MACULAR_CYST

MACULAR_HOLE

MACULAR_PUCKER

MACULA_NAS

10937

H7_MACULADEGEN

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Degeneration of macula and posterior pole based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	10603	5632	4971
Unadjusted prevalence (%)	3.44	3.25	3.68
Mean age at first event (years)	71.08	70.67	71.54

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.89 [1.53, 2.32]	2.2e-9	1514
15 years	0.01	1.03 [0.85, 1.26]	7.4e-1	692
5 years	0.00	2.17 [1.87, 2.51]	3.6e-25	596
1 year	0.00	2.77 [2.26, 3.41]	1.7e-22	157

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_MACULADEGEN – Degeneration of macula and posterior pole
GWS hits: 5

Survival analyses between endpoints

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Plot

before Degeneration of macula and posterior pole
after Degeneration of macula and posterior pole

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Table

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Drugs most likely to be purchased after Degeneration of macula and posterior pole

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