Wet age-related macular degeneration

WET_AMD

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

not WET_AMD_EARLY

321241

Filter registries

Hospital Discharge: ICD-10 H35.31

Hospital discharge: ICD-9 3625B

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 H35.31

Cause of death: ICD-9 3625B

Cause of death: ICD-8 $!$

3512

Check pre-conditions, main-only, mode, ICD version

Pre-conditions EVENT_AGE>=50

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3512

Check minimum number of events None

3512

Include endpoints None

3512

WET_AMD

Extra metadata

Level in the ICD hierarchy 5

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H35

Name in latin Degeneratio maculae senilis exsudativa

Similar endpoints

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List of similar endpoints to Wet age-related macular degeneration based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3418	1793	1625
Unadjusted prevalence (%)	1.11	1.03	1.20
Mean age at first event (years)	75.05	75.29	74.79

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.67 [1.19, 2.35]	3.3e-3	584
15 years	0.01	0.85 [0.63, 1.14]	2.7e-1	255
5 years	0.00	2.01 [1.56, 2.59]	6.0e-8	254
1 year	0.00	2.43 [1.75, 3.37]	9.1e-8	61

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: WET_AMD – Wet age-related macular degeneration
GWS hits: 7

Survival analyses between endpoints

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Plot

before Wet age-related macular degeneration
after Wet age-related macular degeneration

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Wet age-related macular degeneration

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