Dry age-related macular degeneration (includes geographic atrophy)

DRY_AMD

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

not DRY_AMD_EARLY

321203

Filter registries

Hospital Discharge: ICD-10 H35.30

Hospital discharge: ICD-9 3625A

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 H35.30

Cause of death: ICD-9 3625A

Cause of death: ICD-8 $!$

4287

Check pre-conditions, main-only, mode, ICD version

Pre-conditions EVENT_AGE>=50

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4287

Check minimum number of events None

4287

Include endpoints None

4287

DRY_AMD

Extra metadata

Level in the ICD hierarchy 5

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H35

Name in latin Degeneratio maculae senilis atrophica

Similar endpoints

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List of similar endpoints to Dry age-related macular degeneration (includes geographic atrophy) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	4151	2228	1923
Unadjusted prevalence (%)	1.35	1.28	1.42
Mean age at first event (years)	75.02	75.20	74.81

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.39 [1.89, 3.03]	5.7e-13	826
15 years	0.01	1.10 [0.87, 1.38]	4.3e-1	356
5 years	0.00	2.31 [1.93, 2.75]	2.7e-20	348
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DRY_AMD – Dry age-related macular degeneration (includes geographic atrophy)
GWS hits: 5

Survival analyses between endpoints

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Plot

before Dry age-related macular degeneration (includes geographic atrophy)
after Dry age-related macular degeneration (includes geographic atrophy)

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Dry age-related macular degeneration (includes geographic atrophy)

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