Macular hole

MACULAR_HOLE

macular holes: Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 H35.37#
Hospital discharge: ICD-9 3625D
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 H35.37#
Cause of death: ICD-9 3625D
Cause of death: ICD-8 $!$

922

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

922

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Check minimum number of events None

922

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Include endpoints None

922

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MACULAR_HOLE

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35

Summary Statistics

Key figures

All Female Male
Number of individuals 899 529 370
Unadjusted prevalence (%) 0.29 0.30 0.27
Mean age at first event (years) 70.28 68.71 72.52

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.83 [1.28, 6.26] 1.0e-2 39
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: MACULAR_HOLE – Macular hole
GWS hits: 0

Survival analyses between endpoints

Plot

before Macular hole
after Macular hole

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