Macular hole

MACULAR_HOLE

macular holes: Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes.

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H35.37#

Hospital discharge: ICD-9 3625D

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 H35.37#

Cause of death: ICD-9 3625D

Cause of death: ICD-8 $!$

922

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

922

Check minimum number of events None

922

Include endpoints None

922

MACULAR_HOLE

Extra metadata

Level in the ICD hierarchy 5

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H35

Similar endpoints

↥

List of similar endpoints to Macular hole based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	899	529	370
Unadjusted prevalence (%)	0.29	0.30	0.27
Mean age at first event (years)	70.28	68.71	72.52

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.83 [1.28, 6.26]	1.0e-2	39
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: MACULAR_HOLE – Macular hole
GWS hits: 0

Survival analyses between endpoints

↥

Plot

before Macular hole
after Macular hole

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Macular hole

↥