Other extrapyramidal and movement disorders+ in other diseases

G6_XTRAPYROTH

Stiff-Person syndrome: Stiff-man syndrome (SMS) is a rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G25, G26*

Hospital discharge: ICD-9 333

Hospital discharge: ICD-8 $!$

Hospital discharge: excluded ICD-9 3330|3336

Cause of death: ICD-10 G25, G26*

Cause of death: ICD-9 333

Cause of death: ICD-8 $!$

Cause of death: excluded ICD-9 3330|3336

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

3466

G6_XTRAPYROTH

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Other extrapyramidal and movement disorders+ in other diseases based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3374	1816	1558
Unadjusted prevalence (%)	1.09	1.05	1.15
Mean age at first event (years)	59.44	57.29	61.95

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.05 [2.01, 4.63]	1.8e-7	365
15 years	0.01	1.76 [1.22, 2.54]	2.6e-3	177
5 years	0.00	2.89 [2.15, 3.90]	3.2e-12	121
1 year	0.00	4.32 [2.85, 6.55]	5.0e-12	38

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_XTRAPYROTH – Other extrapyramidal and movement disorders+ in other diseases
GWS hits: 0

Survival analyses between endpoints

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Plot

before Other extrapyramidal and movement disorders+ in other diseases
after Other extrapyramidal and movement disorders+ in other diseases

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Table

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Drugs most likely to be purchased after Other extrapyramidal and movement disorders+ in other diseases

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