Paraplegia, diplegia of upper limbs

G6_PARDIPLE

paraplegia: Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord. [database_cross_reference: NCIT:P378]

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 G82.0, G82.1, G82.2, G83.0
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 34401
Cause of death: ICD-10 G82.0, G82.1, G82.2, G83.0
Cause of death: ICD-9 $!$
Cause of death: ICD-8 34401

464

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

464

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Check minimum number of events None

464

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Include endpoints None

464

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G6_PARDIPLE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 453 216 237
Unadjusted prevalence (%) 0.15 0.12 0.18
Mean age at first event (years) 52.23 48.31 55.79

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.10 7.92 [3.17, 19.76] 9.2e-6 91
15 years 0.02 2.40 [0.86, 6.70] 9.4e-2 25
5 years 0.01 4.71 [1.43, 15.49] 1.1e-2 23
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_PARDIPLE – Paraplegia, diplegia of upper limbs
GWS hits: 0

Survival analyses between endpoints

Plot

before Paraplegia, diplegia of upper limbs
after Paraplegia, diplegia of upper limbs

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Drugs most likely to be purchased after Paraplegia, diplegia of upper limbs