Paraplegia, diplegia of upper limbs

G6_PARDIPLE

paraplegia: Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord. [database_cross_reference: NCIT:P378]

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G82.0, G82.1, G82.2, G83.0

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 34401

Cause of death: ICD-10 G82.0, G82.1, G82.2, G83.0

Cause of death: ICD-9 $!$

Cause of death: ICD-8 34401

464

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

464

Check minimum number of events None

464

Include endpoints None

464

G6_PARDIPLE

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Paraplegia, diplegia of upper limbs based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	453	216	237
Unadjusted prevalence (%)	0.15	0.12	0.18
Mean age at first event (years)	52.23	48.31	55.79

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.10	7.92 [3.17, 19.76]	9.2e-6	91
15 years	0.02	2.40 [0.86, 6.70]	9.4e-2	25
5 years	0.01	4.71 [1.43, 15.49]	1.1e-2	23
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_PARDIPLE – Paraplegia, diplegia of upper limbs
GWS hits: 0

Survival analyses between endpoints

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Plot

before Paraplegia, diplegia of upper limbs
after Paraplegia, diplegia of upper limbs

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Table

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Drugs most likely to be purchased after Paraplegia, diplegia of upper limbs

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