Manic episode

F5_MANIA

bipolar disorder: A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F30

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 F30

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

832

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

832

Check minimum number of events None

832

Include endpoints None

832

F5_MANIA

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 F30-F39

Name in latin Mania

Similar endpoints

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List of similar endpoints to Manic episode based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	793	435	358
Unadjusted prevalence (%)	0.26	0.25	0.27
Mean age at first event (years)	43.92	42.86	45.21

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.08	6.02 [3.70, 9.80]	5.1e-13	53
15 years	0.02	2.95 [1.72, 5.05]	8.4e-5	23
5 years	0.00	3.61 [1.73, 7.52]	6.2e-4	13
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_MANIA – Manic episode
GWS hits: 1

Survival analyses between endpoints

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Plot

before Manic episode
after Manic episode

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Manic episode

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