Bipolar affective disorders

F5_BIPO

bipolar disorder: A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F31

Hospital discharge: ICD-9 296[2-7]

Hospital discharge: ICD-8 296

Hospital discharge: excluded ICD-8 2960|29699

Cause of death: ICD-10 F31

Cause of death: ICD-9 296[2-7]

Cause of death: ICD-8 296

Cause of death: excluded ICD-8 2960|29699

7799

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

5975

Check minimum number of events None

5975

Include endpoints None

5975

F5_BIPO

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 F30-F39

Name in latin Perturbatio affectiva bipolaris

Similar endpoints

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List of similar endpoints to Bipolar affective disorders based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	5763	3625	2138
Unadjusted prevalence (%)	1.87	2.09	1.58
Mean age at first event (years)	39.50	38.10	41.86

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.45 [1.57, 3.81]	7.3e-5	256
15 years	0.01	1.92 [1.32, 2.80]	7.2e-4	132
5 years	0.00	2.76 [1.90, 4.02]	1.2e-7	49
1 year	0.00	6.52 [3.96, 10.73]	1.6e-13	21

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_BIPO – Bipolar affective disorders
GWS hits: 0

Survival analyses between endpoints

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Plot

before Bipolar affective disorders
after Bipolar affective disorders

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Table

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Drugs most likely to be purchased after Bipolar affective disorders

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