Graves disease, strict definition

PheWeb

E4_GRAVES_STRICT

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

GRAVES_COND

and not AMIODARONE

9305

Filter registries None

Check pre-conditions, main-only, mode, ICD version None

Check minimum number of events None

Include endpoints

E4_THYTOXGOITDIF

GRAVES_OPHT

2386

E4_GRAVES_STRICT

Extra metadata

First used in FinnGen datafreeze DF7

Similar endpoints

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List of similar endpoints to Graves disease, strict definition based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2311	1963	348
Unadjusted prevalence (%)	0.75	1.13	0.26
Mean age at first event (years)	49.49	48.97	52.44

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.87 [0.82, 4.26]	1.4e-1	54
15 years	0.01	1.29 [0.65, 2.57]	4.6e-1	26
5 years	0.00	2.21 [1.18, 4.16]	1.4e-2	15
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_GRAVES_STRICT – Graves disease, strict definition
GWS hits:

Survival analyses between endpoints

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Plot

before Graves disease, strict definition
after Graves disease, strict definition

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Graves disease, strict definition

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