Gilbert syndrome

E4_GILBERT

Gilbert syndrome: An autosomal recessive inherited disorder characterized by unconjugated hyperbilirubinemia, resulting in harmless intermittent jaundice.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E80.4

Hospital discharge: ICD-9 2774A

Hospital discharge: ICD-8 27350

Cause of death: ICD-10 E80.4

Cause of death: ICD-9 2774A

Cause of death: ICD-8 27350

153

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

147

Check minimum number of events None

147

Include endpoints None

147

E4_GILBERT

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E80

Name in latin Syndroma Gilbert

Similar endpoints

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List of similar endpoints to Gilbert syndrome based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	140	59	81
Unadjusted prevalence (%)	0.05	0.03	0.06
Mean age at first event (years)	42.94	44.50	41.81

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_GILBERT – Gilbert syndrome
GWS hits: 2

Survival analyses between endpoints

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Plot

before Gilbert syndrome
after Gilbert syndrome

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Table

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Drugs most likely to be purchased after Gilbert syndrome

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