Acidosis

E4_ACIDOSIS

lactic acidosis: Metabolic disease characterized by the accumulation of lactate in the body. It is caused by tissue hypoxia

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E87.2

Hospital discharge: ICD-9 2762

Hospital discharge: ICD-8 78869

Cause of death: ICD-10 E87.2

Cause of death: ICD-9 2762

Cause of death: ICD-8 78869

339

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

339

Check minimum number of events None

339

Include endpoints None

339

E4_ACIDOSIS

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E87

Name in latin Acidosis

Similar endpoints

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List of similar endpoints to Acidosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	329	128	201
Unadjusted prevalence (%)	0.11	0.07	0.15
Mean age at first event (years)	61.22	57.80	63.39

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.24	21.76 [10.11, 46.86]	3.5e-15	94
15 years	0.02	4.01 [1.72, 9.35]	1.3e-3	17
5 years	0.01	9.14 [3.83, 21.84]	6.3e-7	22
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_ACIDOSIS – Acidosis
GWS hits: 0

Survival analyses between endpoints

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Plot

before Acidosis
after Acidosis

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Table

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Drugs most likely to be purchased after Acidosis

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