Exclude non-diabetic causes for injection of anti-VEGF-antibody or corticosteroid or any drug into vitreous body

PheWeb

DM_EYE_OPER_FOR_NON_DIAB_EXCLUSION

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

DIABETES_FG

55191

Filter registries

Hospital Discharge: ICD-10 H34.8, H35.31

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 H34.8, H35.31

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

1654

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1654

Check minimum number of events None

1654

Include endpoints None

1654

DM_EYE_OPER_FOR_NON_DIAB_EXCLUSION

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Exclude non-diabetic causes for injection of anti-VEGF-antibody or corticosteroid or any drug into vitreous body based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Retinal vein occlusion (central or branch)

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

1606

771

835

Unadjusted prevalence (%)

0.52

0.44

0.62

Mean age at first event (years)

71.40

71.98

70.88

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Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.51 [2.47, 5.00]	3.3e-12	290
15 years	0.01	1.75 [1.25, 2.46]	1.2e-3	133
5 years	0.00	3.16 [2.24, 4.46]	6.2e-11	120
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DM_EYE_OPER_FOR_NON_DIAB_EXCLUSION – Exclude non-diabetic causes for injection of anti-VEGF-antibody or corticosteroid or any drug into vitreous body
GWS hits:

Survival analyses between endpoints

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Plot

before Exclude non-diabetic causes for injection of anti-VEGF-antibody or corticosteroid or any drug into vitreous body
after Exclude non-diabetic causes for injection of anti-VEGF-antibody or corticosteroid or any drug into vitreous body

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Exclude non-diabetic causes for injection of anti-VEGF-antibody or corticosteroid or any drug into vitreous body

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