Crohn's disease of large intestine

CHRONLARGE

Crohn's colitis: Crohn's disease affecting the colon.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 K50.1
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 K50.1
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

1259

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1259

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Check minimum number of events None

1259

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Include endpoints None

1259

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CHRONLARGE

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K50
Name in latin Colitis regionalis

Summary Statistics

Key figures

All Female Male
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Number of individuals
1220 679 541
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Unadjusted prevalence (%)
0.40 0.39 0.40
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Mean age at first event (years)
43.63 42.38 45.19

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Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.04 [1.14, 3.67] 1.7e-2 48
15 years 0.01 1.25 [0.65, 2.40] 5.0e-1 25
5 years 0.00 2.05 [1.02, 4.14] 4.5e-2 11
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: CHRONLARGE – Crohn's disease of large intestine
GWS hits: 2

Survival analyses between endpoints

Plot

before Crohn's disease of large intestine
after Crohn's disease of large intestine

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Drugs most likely to be purchased after Crohn's disease of large intestine