Asthma-related pneumonia or sepsis

ASTHMA_PNEUMONIA_AND_SEPSIS

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions

J10_ASTHMA

33502

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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ASTHMA_PNEUMONIA_AND_SEPSIS

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 9038 4750 4288
Unadjusted prevalence (%) 2.93 2.74 3.18
Mean age at first event (years) 53.62 51.07 56.44

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.93 [3.05, 5.08] 5.4e-26 1934
15 years 0.01 1.71 [1.37, 2.12] 1.9e-6 636
5 years 0.00 3.62 [2.97, 4.41] 9.8e-38 568
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: ASTHMA_PNEUMONIA_AND_SEPSIS – Asthma-related pneumonia or sepsis
GWS hits: 3

Survival analyses between endpoints

Plot

before Asthma-related pneumonia or sepsis
after Asthma-related pneumonia or sepsis

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Drugs most likely to be purchased after Asthma-related pneumonia or sepsis