Alzheimer’s disease (Early onset)

AD_EO

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F00.0*, F00.00*, F00.00*G30.0, G30.0, G30.0+F00.00

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 F00.0*, F00.00*, F00.00*G30.0, G30.0, G30.0+F00.00

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

933

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

933

Check minimum number of events None

933

Include endpoints None

933

AD_EO

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Alzheimer’s disease (Early onset) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	898	422	476
Unadjusted prevalence (%)	0.29	0.24	0.35
Mean age at first event (years)	74.98	74.06	75.80

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: AD_EO – Alzheimer’s disease (Early onset)
GWS hits: 1

Survival analyses between endpoints

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Plot

before Alzheimer’s disease (Early onset)
after Alzheimer’s disease (Early onset)

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Alzheimer’s disease (Early onset)

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