Alzheimer’s disease (Atypical or mixed)

AD_AM

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F00.24*, G30.8, G30.8+F00.20

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 F00.24*, G30.8, G30.8+F00.20

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

1393

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1393

Check minimum number of events None

1393

Include endpoints None

1393

AD_AM

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Alzheimer’s disease (Atypical or mixed) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1357	560	797
Unadjusted prevalence (%)	0.44	0.32	0.59
Mean age at first event (years)	80.61	81.37	80.08

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	0.59 [0.01, 68.61]	8.3e-1	733
15 years	0.01	1.80 [1.08, 3.00]	2.4e-2	98
5 years	0.01	9.18 [6.98, 12.07]	7.1e-57	338
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: AD_AM – Alzheimer’s disease (Atypical or mixed)
GWS hits: 2

Survival analyses between endpoints

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Plot

before Alzheimer’s disease (Atypical or mixed)
after Alzheimer’s disease (Atypical or mixed)

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Alzheimer’s disease (Atypical or mixed)

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