Diseases of the musculoskeletal system and connective tissue

PheWeb

XIII_MUSCULOSKELET

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M00-M99, M90.6*C40.99, M90.6*C41.99

Hospital discharge: ICD-9 7[1-3]

Hospital discharge: ICD-8 7[1-3]

Cause of death: ICD-10 M00-M99, M90.6*C40.99, M90.6*C41.99

Cause of death: ICD-9 7[1-3]

Cause of death: ICD-8 7[1-3]

177032

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

177032

Check minimum number of events None

177032

Include endpoints None

177032

XIII_MUSCULOSKELET

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Diseases of the musculoskeletal system and connective tissue based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	171249	98738	72511
Unadjusted prevalence (%)	55.50	56.90	53.70
Mean age at first event (years)	46.67	45.36	48.46

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.37 [1.27, 1.47]	2.3e-16	14532
15 years	0.01	0.96 [0.90, 1.03]	3.1e-1	6931
5 years	0.00	1.51 [1.41, 1.63]	9.8e-30	2837
1 year	0.00	2.94 [2.61, 3.32]	2.1e-69	1038

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: XIII_MUSCULOSKELET – Diseases of the musculoskeletal system and connective tissue
GWS hits:

Survival analyses between endpoints

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Plot

before Diseases of the musculoskeletal system and connective tissue
after Diseases of the musculoskeletal system and connective tissue

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Table

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Drugs most likely to be purchased after Diseases of the musculoskeletal system and connective tissue

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