Type 1 diabetes, wide definition, subgroup 2

DOID EFO MESH SNOMED PheWeb

T1D_WIDE2

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

not PANCREATITIS

and not INSULIN_INTER_AND_LONG

and KELA_DIAB_INSUL

and INSULIN_SHORTFAST

491

Filter registries None

Check pre-conditions, main-only, mode, ICD version None

Check minimum number of events None

Include endpoints

T1D_ICD9_10

262

T1D_WIDE2

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Type 1 diabetes, wide definition, subgroup 2 based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Type 1 diabetes, strict definition, subgroup 2

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	250	121	129
Unadjusted prevalence (%)	0.08	0.07	0.10
Mean age at first event (years)	38.57	37.61	39.47

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	4.14 [2.91, 5.90]	3.5e-15	80
15 years	0.02	3.24 [2.25, 4.66]	2.7e-10	53
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: T1D_WIDE2 – Type 1 diabetes, wide definition, subgroup 2
GWS hits: 0

Survival analyses between endpoints

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Plot

before Type 1 diabetes, wide definition, subgroup 2
after Type 1 diabetes, wide definition, subgroup 2

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Table

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Drugs most likely to be purchased after Type 1 diabetes, wide definition, subgroup 2

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