Type 1 diabetes, wide definition, subgroup 1

DOID EFO MESH SNOMED PheWeb

T1D_WIDE1

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

not PANCREATITIS

and KELA_DIAB_INSUL

and INSULIN_SHORTFAST

and INSULIN_INTER_AND_LONG

10149

Filter registries None

Check pre-conditions, main-only, mode, ICD version None

Check minimum number of events None

Include endpoints

T1D_ICD9_10

7181

T1D_WIDE1

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Type 1 diabetes, wide definition, subgroup 1 based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Type 1 diabetes, strict definition, subgroup 1

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	7013	3407	3606
Unadjusted prevalence (%)	2.27	1.96	2.67
Mean age at first event (years)	28.32	26.79	29.76

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.79 [1.08, 2.99]	2.4e-2	550
15 years	0.01	1.26 [0.82, 1.93]	3.0e-1	239
5 years	0.00	0.70 [0.41, 1.20]	1.9e-1	26
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: T1D_WIDE1 – Type 1 diabetes, wide definition, subgroup 1
GWS hits: 30

Survival analyses between endpoints

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Plot

before Type 1 diabetes, wide definition, subgroup 1
after Type 1 diabetes, wide definition, subgroup 1

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Table

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Drugs most likely to be purchased after Type 1 diabetes, wide definition, subgroup 1

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