Adult-onset Still disease

STILL_ADULT

adult-onset Still's disease: adult-onset Still disease (AOSD) is a rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M06.1

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 M06.1

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

STILL_ADULT

Extra metadata

First used in FinnGen datafreeze DF5

Parent code in ICD-10 M06

Name in latin Arthritis rheumatoides seronegativa

Similar endpoints

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List of similar endpoints to Adult-onset Still disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	81	49	32
Unadjusted prevalence (%)	0.03	0.03	0.02
Mean age at first event (years)	48.11	45.73	51.76

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: STILL_ADULT – Adult-onset Still disease
GWS hits: 4

Survival analyses between endpoints

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Plot

before Adult-onset Still disease
after Adult-onset Still disease

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Table

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Drugs most likely to be purchased after Adult-onset Still disease

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