Mental retardation

KRA_PSY_MENTALRET

mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F70-F79

Hospital discharge: ICD-9 31[7-9]

Hospital discharge: ICD-8 31[1-5]

Cause of death: ICD-10 F70-F79

Cause of death: ICD-9 31[7-9]

Cause of death: ICD-8 31[1-5]

1461

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1021

Check minimum number of events None

1021

Include endpoints None

1021

KRA_PSY_MENTALRET

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Mental retardation based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	957	470	487
Unadjusted prevalence (%)	0.31	0.27	0.36
Mean age at first event (years)	26.87	26.85	26.90

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.08	6.46 [3.44, 12.15]	6.7e-9	87
15 years	0.02	3.78 [2.04, 6.99]	2.3e-5	37
5 years	0.01	5.98 [2.65, 13.45]	1.6e-5	18
1 year	0.00	20.39 [8.92, 46.59]	8.8e-13	12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: KRA_PSY_MENTALRET – Mental retardation
GWS hits: 0

Survival analyses between endpoints

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Plot

before Mental retardation
after Mental retardation

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Table

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Drugs most likely to be purchased after Mental retardation

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