Hereditary monor and sensory neuropathy

G6_HEREMOSEN

charcot-marie-tooth disease, axonal, type 2t: ['Charcot-Marie-Tooth disease type 2T (CMT2T) is a slowly progressive autosomal recessive sensorimotor peripheral neuropathy with onset in middle age (Higuchi et al., 2016).']

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G60.0

Hospital discharge: ICD-9 3560

Hospital discharge: ICD-8 33000

Cause of death: ICD-10 G60.0

Cause of death: ICD-9 3560

Cause of death: ICD-8 33000

215

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

170

Check minimum number of events None

170

Include endpoints None

170

G6_HEREMOSEN

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G60

Name in latin Neuropathia motoria et sensoria hereditaria

Similar endpoints

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List of similar endpoints to Hereditary monor and sensory neuropathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	164	92	72
Unadjusted prevalence (%)	0.05	0.05	0.05
Mean age at first event (years)	46.19	43.69	49.38

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_HEREMOSEN – Hereditary monor and sensory neuropathy
GWS hits: 2

Survival analyses between endpoints

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Plot

before Hereditary monor and sensory neuropathy
after Hereditary monor and sensory neuropathy

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Table

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Drugs most likely to be purchased after Hereditary monor and sensory neuropathy

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