Dementia in Alzheimer disease

F5_ALZHDEMENT

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F00*

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 29010

Cause of death: ICD-10 F00*

Cause of death: ICD-9 $!$

Cause of death: ICD-8 29010

3673

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3673

Check minimum number of events None

3673

Include endpoints None

3673

F5_ALZHDEMENT

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Dementia in Alzheimer disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Alzheimer’s disease (undefined)

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3540	1632	1908
Unadjusted prevalence (%)	1.15	0.94	1.41
Mean age at first event (years)	79.54	79.96	79.18

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.13	9.79 [6.79, 14.12]	2.3e-34	1917
15 years	0.02	2.56 [1.86, 3.50]	5.5e-9	449
5 years	0.01	8.17 [7.02, 9.50]	<1e-100	968
1 year	0.00	14.79 [12.68, 17.25]	<1e-100	499

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_ALZHDEMENT – Dementia in Alzheimer disease
GWS hits: 2

Survival analyses between endpoints

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Plot

before Dementia in Alzheimer disease
after Dementia in Alzheimer disease

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Table

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Drugs most likely to be purchased after Dementia in Alzheimer disease

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