obsolete_dementia: ['An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.']

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 F00-F09
Hospital discharge: ICD-9 290|3310|4378A
Hospital discharge: ICD-8 290
Cause of death: ICD-10 F00-F09
Cause of death: ICD-9 290|3310|4378A
Cause of death: ICD-8 290
KELA reimbursements: KELA codes 307
Medicine purchases: ATC N06D


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events

Min. number of events 3


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Include endpoints


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 11602 5137 6465
Unadjusted prevalence (%) 3.76 2.96 4.79
Mean age at first event (years) 77.05 77.45 76.73


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.11 7.79 [6.88, 8.82] <1e-100 5218
15 years 0.02 2.67 [2.35, 3.04] 7.9e-50 1517
5 years 0.01 6.30 [5.70, 6.96] <1e-100 2503
1 year 0.00 10.95 [9.74, 12.31] <1e-100 1180

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: F5_DEMENTIA – Dementia
GWS hits: 3

Survival analyses between endpoints


before Dementia
after Dementia

loading spinner Loading survival analyses plot