Dementia

F5_DEMENTIA

obsolete_dementia: ['An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.']

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F00-F09

Hospital discharge: ICD-9 290|3310|4378A

Hospital discharge: ICD-8 290

Cause of death: ICD-10 F00-F09

Cause of death: ICD-9 290|3310|4378A

Cause of death: ICD-8 290

KELA reimbursements: KELA codes 307

Medicine purchases: ATC N06D

12663

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

11998

Check minimum number of events

Min. number of events 3

11998

Include endpoints

F5_ALZHDEMENT

F5_VASCDEM

F5_DEMINOTH

F5_DEMNAS

12026

F5_DEMENTIA

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Dementia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	11602	5137	6465
Unadjusted prevalence (%)	3.76	2.96	4.79
Mean age at first event (years)	77.05	77.45	76.73

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.11	7.79 [6.88, 8.82]	<1e-100	5218
15 years	0.02	2.67 [2.35, 3.04]	7.9e-50	1517
5 years	0.01	6.30 [5.70, 6.96]	<1e-100	2503
1 year	0.00	10.95 [9.74, 12.31]	<1e-100	1180

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_DEMENTIA – Dementia
GWS hits: 3

Survival analyses between endpoints

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Plot

before Dementia
after Dementia

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Dementia

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