Other and/or unspecified nontoxic goitre

E4_GOITRENAS

goiter: Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E04.8, E04.9

Hospital discharge: ICD-9 2419

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 E04.8, E04.9

Cause of death: ICD-9 2419

Cause of death: ICD-8 $!$

2684

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1910

Check minimum number of events None

1910

Include endpoints None

1910

E4_GOITRENAS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Other and/or unspecified nontoxic goitre based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1841	1557	284
Unadjusted prevalence (%)	0.60	0.90	0.21
Mean age at first event (years)	54.62	53.59	60.28

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.82 [1.16, 2.86]	9.2e-3	117
15 years	0.01	1.05 [0.68, 1.62]	8.3e-1	45
5 years	0.00	2.33 [1.52, 3.58]	9.7e-5	29
1 year	0.00	5.95 [3.33, 10.63]	1.6e-9	15

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_GOITRENAS – Other and/or unspecified nontoxic goitre
GWS hits: 5

Survival analyses between endpoints

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Plot

before Other and/or unspecified nontoxic goitre
after Other and/or unspecified nontoxic goitre

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Table

Loading survival analyses table

Drugs most likely to be purchased after Other and/or unspecified nontoxic goitre

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