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Type 1 diabetes with ophthalmic complications

DOIDEFOMESHSNOMED PheWeb

E4_DM1OPTH

diabetic retinopathy: A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness.

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 E10.3+, E10.3+H28.0, E10.3+H36.09
Hospital discharge: ICD-9 2504B
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E10.3+, E10.3+H28.0, E10.3+H36.09
Cause of death: ICD-9 2504B
Cause of death: ICD-8 $!$

4292

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4292

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Check minimum number of events None

4292

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Include endpoints None

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E4_DM1OPTH

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 4204 2179 2025
Unadjusted prevalence (%) 1.36 1.26 1.50
Mean age at first event (years) 37.59 36.37 38.90

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 6.82 [4.32, 10.75] 1.5e-16 359
15 years 0.03 4.62 [3.24, 6.59] 3.5e-17 190
5 years 0.01 6.30 [4.48, 8.87] 5.3e-26 77
1 year 0.00 8.52 [5.09, 14.28] 4.1e-16 19

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1OPTH – Type 1 diabetes with ophthalmic complications
GWS hits: 27

Survival analyses between endpoints

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Plot

before Type 1 diabetes with ophthalmic complications
after Type 1 diabetes with ophthalmic complications

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Type 1 diabetes with ophthalmic complications

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