Type 1 diabetes with ketoacidosis

E4_DM1KETO

diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E10.1

Hospital discharge: ICD-9 2501B

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 E10.1

Cause of death: ICD-9 2501B

Cause of death: ICD-8 $!$

1816

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1816

Check minimum number of events None

1816

Include endpoints None

1816

E4_DM1KETO

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF3

Parent code in ICD-10 E10

Similar endpoints

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List of similar endpoints to Type 1 diabetes with ketoacidosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1781	887	894
Unadjusted prevalence (%)	0.58	0.51	0.66
Mean age at first event (years)	25.27	24.35	26.19

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.43	43.32 [28.55, 65.73]	3.3e-70	176
15 years	0.12	20.06 [12.59, 31.97]	1.7e-36	70
5 years	0.03	26.57 [14.22, 49.63]	8.0e-25	39
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1KETO – Type 1 diabetes with ketoacidosis
GWS hits: 15

Survival analyses between endpoints

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Plot

before Type 1 diabetes with ketoacidosis
after Type 1 diabetes with ketoacidosis

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Table

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Drugs most likely to be purchased after Type 1 diabetes with ketoacidosis

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