Diabetes, varying definitions

DIABETES_FG

diabetes mellitus: A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

55191

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DIABETES_FG

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 53388 24164 29224
Unadjusted prevalence (%) 17.30 13.93 21.64
Mean age at first event (years) 54.77 53.16 56.10

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.55 [2.31, 2.81] 4.0e-79 8048
15 years 0.01 1.75 [1.61, 1.90] 1.9e-38 4051
5 years 0.00 2.73 [2.52, 2.95] <1e-100 1983
1 year 0.00 4.75 [4.19, 5.39] <1e-100 677

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: DIABETES_FG – Diabetes, varying definitions
GWS hits: 106

Survival analyses between endpoints

Plot

before Diabetes, varying definitions
after Diabetes, varying definitions

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Drugs most likely to be purchased after Diabetes, varying definitions