Other diabetes, wide definition

DM_OTHER_WIDE

Takayasu arteritis: Takayasu arteritis (TAK) is a rare inflammatory large-vessel vasculitis primarily affecting the aorta and its major branches, but also other large vessels, causing stenosis, occlusion, or aneurysm.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

not GEST_DIABETES

311448

Filter registries

Hospital Discharge: ICD-10 E13

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 E13

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

938

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

806

Check minimum number of events None

806

Include endpoints

DIAB_MED

48532

DM_OTHER_WIDE

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Other diabetes, wide definition based on the number of shared cases.

Broader endpoints:

Diabetes, varying definitions

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	47004	20078	26926
Unadjusted prevalence (%)	15.23	11.57	19.94
Mean age at first event (years)	56.44	56.13	56.68

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.30 [2.07, 2.57]	2.4e-51	6959
15 years	0.01	1.64 [1.50, 1.80]	1.4e-25	3749
5 years	0.00	2.39 [2.19, 2.60]	8.7e-88	1731
1 year	0.00	1.93 [1.65, 2.25]	2.3e-16	273

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DM_OTHER_WIDE – Other diabetes, wide definition
GWS hits: 89

Survival analyses between endpoints

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Plot

before Other diabetes, wide definition
after Other diabetes, wide definition

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Other diabetes, wide definition

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