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Other disorders of white blood cells

DOIDEFOMESHSNOMED PheWeb

D3_OTHERWHITECELL

Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 D72
Cause of death: ICD-10 D72

1062

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

1062

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Check minimum number of events None

1062

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Include endpoints

1139

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D3_OTHERWHITECELL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D70-D77
Name in latin Aliae morbositates leucocytorum

Similar endpoints

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List of similar endpoints to Other disorders of white blood cells based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 1086 587 499
Unadjusted prevalence (%) 0.35 0.34 0.37
Mean age at first event (years) 54.25 51.13 57.93

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.10 [0.85, 5.17] 1.1e-1 134
15 years 0.01 1.02 [0.42, 2.48] 9.7e-1 48
5 years 0.00 3.97 [2.14, 7.38] 1.3e-5 52
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_OTHERWHITECELL – Other disorders of white blood cells
GWS hits: 1

Survival analyses between endpoints

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Plot

before Other disorders of white blood cells
after Other disorders of white blood cells

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Drugs most likely to be purchased after Other disorders of white blood cells

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