Eosinophilia

D3_EOSINOPHILIA

Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D72.1

Hospital discharge: ICD-9 2883

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 D72.1

Cause of death: ICD-9 2883

Cause of death: ICD-8 $!$

314

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

314

Check minimum number of events None

314

Include endpoints None

314

D3_EOSINOPHILIA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D72

Name in latin Eosinophilia

Similar endpoints

↥

List of similar endpoints to Eosinophilia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Eosinophilic disease (BM)

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	303	168	135
Unadjusted prevalence (%)	0.10	0.10	0.10
Mean age at first event (years)	53.73	51.41	56.61

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.63 [2.05, 6.43]	1.0e-5	26
15 years	0.01	1.64 [0.82, 3.26]	1.6e-1	10
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: D3_EOSINOPHILIA – Eosinophilia
GWS hits: 0

Survival analyses between endpoints

↥

Plot

before Eosinophilia
after Eosinophilia

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Eosinophilia

↥