Eosinophilic disease (BM)


Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 D72.1
Hospital discharge: ICD-9 2883
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 D72.1
Cause of death: ICD-9 2883
Cause of death: ICD-8 $!$


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 D72
Name in latin Eosinophilia

Summary Statistics

Key figures

All Female Male
Number of individuals 303 168 135
Unadjusted prevalence (%) 0.10 0.10 0.10
Mean age at first event (years) 53.73 51.41 56.61


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.29 [1.04, 5.00] 3.9e-2 26
15 years 0.01 1.17 [0.54, 2.56] 6.9e-1 10
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: ESOSINOPHIL_DISEASE – Eosinophilic disease (BM)
GWS hits: 0

Survival analyses between endpoints


before Eosinophilic disease (BM)
after Eosinophilic disease (BM)

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Drugs most likely to be purchased after Eosinophilic disease (BM)