Chron's disease NAS

CHRONNAS

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K50.9

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 K50.9

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

1585

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1585

Check minimum number of events None

1585

Include endpoints None

1585

CHRONNAS

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K50

Name in latin Morbus Crohn non specificatus

Similar endpoints

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List of similar endpoints to Chron's disease NAS based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1545	855	690
Unadjusted prevalence (%)	0.50	0.49	0.51
Mean age at first event (years)	44.16	43.02	45.57

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.92 [2.55, 6.03]	4.4e-10	89
15 years	0.01	1.57 [0.95, 2.60]	7.8e-2	30
5 years	0.00	4.66 [2.97, 7.31]	2.2e-11	35
1 year	0.00	10.35 [5.85, 18.29]	9.1e-16	19

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CHRONNAS – Chron's disease NAS
GWS hits: 3

Survival analyses between endpoints

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Plot

before Chron's disease NAS
after Chron's disease NAS

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Table

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Drugs most likely to be purchased after Chron's disease NAS

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