Non-allergic asthma

ASTHMA_NONALLERG

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

Check conditions

not L12_ATOPIC

and not ALLERG_RHINITIS

and not H7_ALLERGICCONJUNCTIVITIS

and not FOOD_ALLERGY

and not Z21_DESEN_ALLERGE

and not POLLENALLERG

Filter registries None

Check pre-conditions, main-only, mode, ICD version None

Check minimum number of events None

Include endpoints

NONALLERG_ASTHMA

5865

ASTHMA_NONALLERG

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Non-allergic asthma based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Non-allergic asthma (mode)

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	8833	5479	3354
Unadjusted prevalence (%)	2.86	3.16	2.48
Mean age at first event (years)	48.80	47.56	50.82

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.17 [1.75, 2.70]	2.9e-12	945
15 years	0.01	1.51 [1.25, 1.83]	1.9e-5	493
5 years	0.00	2.80 [2.34, 3.33]	3.5e-30	266
1 year	0.00	3.28 [2.45, 4.39]	1.2e-15	60

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ASTHMA_NONALLERG – Non-allergic asthma
GWS hits: 0

Survival analyses between endpoints

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Plot

before Non-allergic asthma
after Non-allergic asthma

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Non-allergic asthma

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