Non-allergic asthma

ASTHMA_NONALLERG

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

FinnGen phenotype data

321302 individuals

diagram downward connector

Apply sex-specific rule None

diagram downward connector
diagram bullet

Check conditions

not L12_ATOPIC
and not ALLERG_RHINITIS
and not H7_ALLERGICCONJUNCTIVITIS
and not FOOD_ALLERGY
and not Z21_DESEN_ALLERGE
and not POLLENALLERG

diagram downward connector

Filter registries None

0

diagram downward connector

Check pre-conditions, main-only, mode, ICD version None

0

diagram downward connector

Check minimum number of events None

0

diagram downward connector
diagram bullet diagram downward connector

Include endpoints

5865

diagram downward connector
ASTHMA_NONALLERG

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 8833 5479 3354
Unadjusted prevalence (%) 2.86 3.16 2.48
Mean age at first event (years) 48.80 47.56 50.82

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.17 [1.75, 2.70] 2.9e-12 945
15 years 0.01 1.51 [1.25, 1.83] 1.9e-5 493
5 years 0.00 2.80 [2.34, 3.33] 3.5e-30 266
1 year 0.00 3.28 [2.45, 4.39] 1.2e-15 60

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: ASTHMA_NONALLERG – Non-allergic asthma
GWS hits: 0

Survival analyses between endpoints

Plot

before Non-allergic asthma
after Non-allergic asthma

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Non-allergic asthma