Non-allergic asthma (mode)

NONALLERG_ASTHMA

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 J45.1

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 J45.1

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

30214

Check pre-conditions, main-only, mode, ICD version

Check mode of ICD-10 codes: %J451

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

5865

Check minimum number of events None

5865

Include endpoints None

5865

NONALLERG_ASTHMA

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Non-allergic asthma (mode) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Non-allergic asthma

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	8833	5479	3354
Unadjusted prevalence (%)	2.86	3.16	2.48
Mean age at first event (years)	48.80	47.56	50.82

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.11 [1.55, 2.87]	1.7e-6	945
15 years	0.01	1.47 [1.10, 1.96]	1.0e-2	493
5 years	0.00	2.62 [2.08, 3.30]	3.0e-16	266
1 year	0.00	3.05 [2.22, 4.20]	7.3e-12	60

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: NONALLERG_ASTHMA – Non-allergic asthma (mode)
GWS hits: 1

Survival analyses between endpoints

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Plot

before Non-allergic asthma (mode)
after Non-allergic asthma (mode)

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Non-allergic asthma (mode)

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