Alzheimer’s disease (Atypical or mixed)

AD_AM

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 F00.24*, G30.8, G30.8+F00.20
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 F00.24*, G30.8, G30.8+F00.20
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

1393

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1393

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Check minimum number of events None

1393

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Include endpoints None

1393

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AD_AM

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1357 560 797
Unadjusted prevalence (%) 0.44 0.32 0.59
Mean age at first event (years) 80.61 81.37 80.08

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 0.59 [0.01, 68.61] 8.3e-1 733
15 years 0.01 1.80 [1.08, 3.00] 2.4e-2 98
5 years 0.01 9.18 [6.98, 12.07] 7.1e-57 338
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: AD_AM – Alzheimer’s disease (Atypical or mixed)
GWS hits: 2

Survival analyses between endpoints

Plot

before Alzheimer’s disease (Atypical or mixed)
after Alzheimer’s disease (Atypical or mixed)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Alzheimer’s disease (Atypical or mixed)