Respiratory insufficiency


respiratory failure: The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function. [NCIT:C26872]

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 J96.1
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 J96.1
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 J96
Name in latin Insufficientia respiratoria chronica

Summary Statistics

Key figures

All Female Male
Number of individuals 1651 584 1067
Unadjusted prevalence (%) 0.54 0.34 0.79
Mean age at first event (years) 69.34 66.66 70.81


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.27 24.59 [18.81, 32.14] <1e-100 803
15 years 0.02 3.58 [2.67, 4.79] 9.0e-18 108
5 years 0.02 16.10 [13.05, 19.86] <1e-100 334
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: RESPIRATORYINSUFF – Respiratory insufficiency
GWS hits: 0

Survival analyses between endpoints


before Respiratory insufficiency
after Respiratory insufficiency

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Drugs most likely to be purchased after Respiratory insufficiency