Respiratory insufficiency

RESPIRATORYINSUFF

respiratory failure: The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function. [NCIT:C26872]

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 J96.1

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 J96.1

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

1703

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1703

Check minimum number of events None

1703

Include endpoints None

1703

RESPIRATORYINSUFF

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 J96

Name in latin Insufficientia respiratoria chronica

Similar endpoints

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List of similar endpoints to Respiratory insufficiency based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1651	584	1067
Unadjusted prevalence (%)	0.54	0.34	0.79
Mean age at first event (years)	69.34	66.66	70.81

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.27	24.59 [18.81, 32.14]	<1e-100	803
15 years	0.02	3.58 [2.67, 4.79]	9.0e-18	108
5 years	0.02	16.10 [13.05, 19.86]	<1e-100	334
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RESPIRATORYINSUFF – Respiratory insufficiency
GWS hits: 0

Survival analyses between endpoints

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Plot

before Respiratory insufficiency
after Respiratory insufficiency

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Table

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Drugs most likely to be purchased after Respiratory insufficiency

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