Nonalcoholic steatohepatitis

NASH

Hepatitis, Alcoholic: INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K73.80

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 K73.80

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

101

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

101

Check minimum number of events None

101

Include endpoints None

101

NASH

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K73

Similar endpoints

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List of similar endpoints to Nonalcoholic steatohepatitis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	99	62	37
Unadjusted prevalence (%)	0.03	0.04	0.03
Mean age at first event (years)	56.95	57.79	55.55

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: NASH – Nonalcoholic steatohepatitis
GWS hits:

Survival analyses between endpoints

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Plot

before Nonalcoholic steatohepatitis
after Nonalcoholic steatohepatitis

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Table

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Drugs most likely to be purchased after Nonalcoholic steatohepatitis

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