Villonodular synovitis (pigmented)


pigmented villonodular synovitis: Pigmented villonodular synovitis (PVNS) is a rare benign proliferative disorder of the synovial membrane primarily affecting young adults (with a peak age of onset in the second to fourth decade of life) characterized by proliferative, locally invasive tumor-like lesions, usually involving a single joint, tendon sheath or bursae (most commonly the joints of the knee and hip and rarely others such as the ankle, shoulder and temporomandibular joints). It presents with pain and limitation of motion along with swelling, heat and tenderness over the involved joint, eventually leading to arthritic degeneration and significant locomotor deficit, if left untreated. PVNS can recur in patients even after treatment.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 M12.2
Hospital discharge: ICD-9 7192
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 M12.2
Cause of death: ICD-9 7192
Cause of death: ICD-8 $!$


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M12
Name in latin Synovitis villonodularis [pigmentata]

Summary Statistics

Key figures

All Female Male
Number of individuals 162 104 58
Unadjusted prevalence (%) 0.05 0.06 0.04
Mean age at first event (years) 40.93 40.48 41.75


Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: M13_VILLONODULAR – Villonodular synovitis (pigmented)
GWS hits: 0

Survival analyses between endpoints


before Villonodular synovitis (pigmented)
after Villonodular synovitis (pigmented)

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Drugs most likely to be purchased after Villonodular synovitis (pigmented)