Disorders of muscles

M13_MUSCLE

myositis: An inflammatory disease involving a pathogenic inflammatory response in the muscle tissue.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 M60-M63
Cause of death: ICD-10 M60-M63

1863

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

1863

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Check minimum number of events None

1863

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M13_MUSCLE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Disorders of muscles based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

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Summary Statistics

Key figures

All Female Male
Number of individuals 2252 1186 1066
Unadjusted prevalence (%) 0.73 0.68 0.79
Mean age at first event (years) 48.93 47.88 50.09

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.21 [0.44, 3.31] 7.2e-1 193
15 years 0.01 0.82 [0.34, 1.96] 6.5e-1 78
5 years 0.00 1.93 [1.01, 3.69] 4.6e-2 49
1 year 0.00 8.36 [4.51, 15.50] 1.6e-11 40

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_MUSCLE – Disorders of muscles
GWS hits: 0

Survival analyses between endpoints

Plot

before Disorders of muscles
after Disorders of muscles

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Drugs most likely to be purchased after Disorders of muscles