Giant cell arteritis

M13_GIANTCELL

temporal arteritis: Giant cell arteritis (GCA) is a large vessel vasculitis predominantly involving the arteries originating from the aortic arch and especially the extracranial branches of the carotid arteries.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M31.5, M31.6

Hospital discharge: ICD-9 4465

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 M31.5, M31.6

Cause of death: ICD-9 4465

Cause of death: ICD-8 $!$

778

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

778

Check minimum number of events None

778

Include endpoints

M13_TEMPARTERIT

778

M13_GIANTCELL

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Giant cell arteritis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Temporal arteritis

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	759	459	300
Unadjusted prevalence (%)	0.25	0.26	0.22
Mean age at first event (years)	68.04	67.40	69.03

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.45 [1.38, 4.33]	2.2e-3	111
15 years	0.01	1.12 [0.61, 2.04]	7.2e-1	47
5 years	0.00	2.69 [1.73, 4.20]	1.1e-5	41
1 year	0.00	6.17 [3.58, 10.64]	5.6e-11	19

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_GIANTCELL – Giant cell arteritis
GWS hits: 0

Survival analyses between endpoints

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Plot

before Giant cell arteritis
after Giant cell arteritis

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Table

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Drugs most likely to be purchased after Giant cell arteritis

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