Coxarthrosis,

M13_ARTHTROSIS_COX

osteoarthritis: A noninflammatory degenerative joint disease occurring chiefly in older persons, characterised by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M16

Hospital discharge: ICD-9 7151E|7152E

Hospital discharge: ICD-8 71300

Cause of death: ICD-10 M16

Cause of death: ICD-9 7151E|7152E

Cause of death: ICD-8 71300

17131

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

17131

Check minimum number of events None

17131

Include endpoints None

17131

M13_ARTHTROSIS_COX

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M15-M19

Name in latin Coxarthrosis

Similar endpoints

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List of similar endpoints to Coxarthrosis, based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	16649	9013	7636
Unadjusted prevalence (%)	5.40	5.19	5.66
Mean age at first event (years)	63.77	63.57	64.00

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.28 [1.06, 1.56]	1.1e-2	1916
15 years	0.01	0.90 [0.77, 1.06]	2.2e-1	1017
5 years	0.00	1.39 [1.20, 1.60]	7.9e-6	476
1 year	0.00	1.72 [1.38, 2.16]	1.7e-6	113

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_ARTHTROSIS_COX – Coxarthrosis,
GWS hits: 14

Survival analyses between endpoints

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Plot

before Coxarthrosis,
after Coxarthrosis,

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Table

Loading survival analyses table

Drugs most likely to be purchased after Coxarthrosis,

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