osteoarthritis: A noninflammatory degenerative joint disease occurring chiefly in older persons, characterised by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 M16
Hospital discharge: ICD-9 7151E|7152E
Hospital discharge: ICD-8 71300
Cause of death: ICD-10 M16
Cause of death: ICD-9 7151E|7152E
Cause of death: ICD-8 71300


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M15-M19
Name in latin Coxarthrosis

Summary Statistics

Key figures

All Female Male
Number of individuals 16649 9013 7636
Unadjusted prevalence (%) 5.40 5.19 5.66
Mean age at first event (years) 63.77 63.57 64.00


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.28 [1.06, 1.56] 1.1e-2 1916
15 years 0.01 0.90 [0.77, 1.06] 2.2e-1 1017
5 years 0.00 1.39 [1.20, 1.60] 7.9e-6 476
1 year 0.00 1.72 [1.38, 2.16] 1.7e-6 113

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: M13_ARTHTROSIS_COX – Coxarthrosis,
GWS hits: 14

Survival analyses between endpoints


before Coxarthrosis,
after Coxarthrosis,

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