Bullous disorders


vesiculobullous skin disease: Skin diseases characterized by local or general distributions of vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, distinguished by size (vesicles being less than 5–10 mm and bullae being larger than 5–10 mm). Vesiculobullous diseases are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous is sometimes used. (From Scientific American Medicine, 1990, and Wikipedia)

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 L10-L14
Cause of death: ICD-10 L10-L14


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10


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Check minimum number of events None


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Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1123 612 511
Unadjusted prevalence (%) 0.36 0.35 0.38
Mean age at first event (years) 56.24 53.84 59.13


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.35 [1.31, 4.22] 4.1e-3 152
15 years 0.01 0.93 [0.55, 1.58] 7.9e-1 45
5 years 0.00 2.94 [1.95, 4.44] 3.0e-7 51
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: L12_BULLOUS – Bullous disorders
GWS hits: 2

Survival analyses between endpoints


before Bullous disorders
after Bullous disorders

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Drugs most likely to be purchased after Bullous disorders