Dermatitis herpetiformis

L12_DERMATHERP

dermatitis herpetiformis: Dermatitis herpetiformis (DH) is a chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. DH may also appear as a consequence of gluten intolerance.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 L13.0

Hospital discharge: ICD-9 6940A|6942

Hospital discharge: ICD-8 693

Cause of death: ICD-10 L13.0

Cause of death: ICD-9 6940A|6942

Cause of death: ICD-8 693

622

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

412

Check minimum number of events None

412

Include endpoints None

412

L12_DERMATHERP

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 L13

Name in latin Dermatitis herpetiformis

Similar endpoints

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List of similar endpoints to Dermatitis herpetiformis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	401	231	170
Unadjusted prevalence (%)	0.13	0.13	0.13
Mean age at first event (years)	44.79	42.50	47.89

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.73 [0.20, 2.67]	6.4e-1	31
15 years	0.00	0.71 [0.23, 2.18]	5.5e-1	18
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: L12_DERMATHERP – Dermatitis herpetiformis
GWS hits: 8

Survival analyses between endpoints

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Plot

before Dermatitis herpetiformis
after Dermatitis herpetiformis

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Table

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Drugs most likely to be purchased after Dermatitis herpetiformis

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