Substance abuse

DOID MESH PheWeb

KRA_PSY_SUBSTANCE

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F10-F19

Hospital discharge: ICD-9 29[1-2]|30[3-5]

Hospital discharge: ICD-8 291|30[3-4]

Hospital discharge: excluded ICD-10 F10.0

Hospital discharge: excluded ICD-9 3050A

Cause of death: ICD-10 F10-F19

Cause of death: ICD-9 29[1-2]|30[3-5]

Cause of death: ICD-8 291|30[3-4]

18273

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

17878

Check minimum number of events None

17878

Include endpoints

KRA_PSY_ALCOH

19140

KRA_PSY_SUBSTANCE

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Substance abuse based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	18505	6503	12002
Unadjusted prevalence (%)	6.00	3.75	8.89
Mean age at first event (years)	44.44	41.23	46.18

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	5.46 [4.55, 6.54]	1.6e-75	3143
15 years	0.02	3.15 [2.72, 3.65]	6.5e-53	1226
5 years	0.00	5.58 [4.94, 6.30]	<1e-100	710
1 year	0.00	0.43 [0.07, 2.43]	3.4e-1	734

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: KRA_PSY_SUBSTANCE – Substance abuse
GWS hits: 3

Survival analyses between endpoints

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Plot

before Substance abuse
after Substance abuse

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Table

Loading survival analyses table

Drugs most likely to be purchased after Substance abuse

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