Alcohol dependence

DOID EFO MESH SNOMED PheWeb

F5_ALCOHOL_DEPENDENCE

alcohol dependence: Physical and psychological dependence on alcohol.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F10.2

Hospital discharge: ICD-9 303

Hospital discharge: ICD-8 303

Cause of death: ICD-10 F10.2

Cause of death: ICD-9 303

Cause of death: ICD-8 303

8362

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

8362

Check minimum number of events None

8362

Include endpoints None

8362

F5_ALCOHOL_DEPENDENCE

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF3

Parent code in ICD-10 F10

Similar endpoints

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List of similar endpoints to Alcohol dependence based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	8137	2271	5866
Unadjusted prevalence (%)	2.64	1.31	4.34
Mean age at first event (years)	42.84	40.94	43.58

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	4.24 [3.32, 5.42]	5.9e-31	1625
15 years	0.01	2.65 [2.15, 3.28]	1.4e-19	683
5 years	0.00	4.85 [4.10, 5.74]	6.3e-76	350
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_ALCOHOL_DEPENDENCE – Alcohol dependence
GWS hits: 3

Survival analyses between endpoints

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Plot

before Alcohol dependence
after Alcohol dependence

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Table

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Drugs most likely to be purchased after Alcohol dependence

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